Vessel isolation device

The device utilizes a reversibly expandable body partially covered by a blood impermeable sleeve. The device has a low profile collapsed state for delivery and a expanded state for deployment. The impermeable sleeve extends from a proximal portion to a distal portion of the expandable body and generally follows the contour of the expandable body. When deployed, the device is configured in the expanded state and has a generally hourglass, or dumbbell shape. In the expanded state, portions of the sleeve adjacent to the proximal and distal portions are placed in apposition to a vessel wall and blood is free to flow through the expandable body via inlets and outlets provided in the proximal and distal portions. As a result, an isolated treatment space is created that surrounds the device between the vessel wall and the blood impermeable sleeve adjacent to the neck portion of the expandable body.