Radioactive arsenic-containing compounds and their uses in the treatment of tumors

This invention provides a process for producing a radioactive arsenic-containing compound, comprising the steps of: (i) subjecting an arsenic-containing compound to a neutron irradiation treatment, said arsenic-containing compound being selected from a group consisting of As2O3, As2S3, As2S2, and a...

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Hauptverfasser: HSU WEIUAN, FAN KUO-HSIEN, KAO CHARNG-FENG, HUANG CHUN-YING, CHANG CHIH-HSIEN, HSU YIN-MAO, WU MING-SHIUAN, CHEN TE-JUNG, CHANG SHIANG-RONG, CHYI SHYH-YI, CHANG KWO-PING, FU YING-KAI, LEE TE-WEI
Format: Patent
Sprache:eng
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Zusammenfassung:This invention provides a process for producing a radioactive arsenic-containing compound, comprising the steps of: (i) subjecting an arsenic-containing compound to a neutron irradiation treatment, said arsenic-containing compound being selected from a group consisting of As2O3, As2S3, As2S2, and a combination thereof, such that the arsenic element contained in the arsenic-containing compound is converted to a radioactive arsenic isotope; and (ii) recovering the resultant product from step (i). This invention also provides a pharmaceutical composition comprising a therapeutically effective amount of the radioactive arsenic-containing compound and a pharmaceutically acceptable carrier. The pharmaceutical composition can be used in the treatment of tumors/cancers such as hematological malignancies and solid tumors.