Detection of oligonucleotides by dual hybridization

The invention provides methods and compositions for detecting and/or quantifying modified nucleic acid oligonucleotides. These methods and compositions are useful for detecting and quantifying diagnostic and/or therapeutic synthetic modified oligonucleotides, such as aptamers, RNAi, siRNA, antisense...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: SHIMA DAVID T, SINANI ERVIN, CALIAS PERICLES, SMITH LILLIAN M, WING JOHN P, ROBINSON GREGORY S, MULLIN LORI M
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The invention provides methods and compositions for detecting and/or quantifying modified nucleic acid oligonucleotides. These methods and compositions are useful for detecting and quantifying diagnostic and/or therapeutic synthetic modified oligonucleotides, such as aptamers, RNAi, siRNA, antisense oligonucleotides or ribozymes in a biological sample.