Method of identifying a chemical entity which is a hydroxylase modulator

A method of identifying, screening, characterising or designing a chemical entity, which mimics or binds to FIH, is described. The method comprises comparing a structural model of FIH with a structural model for said chemical entity, wherein said structural model of FIH is derived from structural fa...

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Bibliographische Detailangaben
Hauptverfasser:	PUGH CHRISTOPHER WILLIAM, RATCLIFFE PETER JOHN, SCHOFIELD CHRISTOPHER JOSEPH, HEWITSON KIRSTY SARAH, ELKINS JONATHAN MARK
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CALCULATING CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPUTING CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CONTROLLING COUNTING ELECTRIC DIGITAL DATA PROCESSING ENZYMOLOGY GYROSCOPIC INSTRUMENTS INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING DISTANCES, LEVELS OR BEARINGS MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING NAVIGATION PHOTOGRAMMETRY OR VIDEOGRAMMETRY PHYSICS PROCESSES OF PREPARING SUCH COMPOSITIONS REGULATING SPIRITS SURVEYING SYSTEMS FOR CONTROLLING OR REGULATING NON-ELECTRIC VARIABLES TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	A method of identifying, screening, characterising or designing a chemical entity, which mimics or binds to FIH, is described. The method comprises comparing a structural model of FIH with a structural model for said chemical entity, wherein said structural model of FIH is derived from structural factors or structural coordinates determined by subjecting to X-ray diffraction measurements a crystal comprising FIH. Such chemical entities may be used in the treatment of a condition associated with increased or decreased HIF levels or activity.