Substituted pyrazolo[1,5-a]pyrimidines as protein kinase inhibitors

In its many embodiments, the present invention provides a novel class of amino-substituted pyrazolo[1,5-a]pyrimidine compounds as inhibitors of protein and/or checkpoint kinases, methods of preparing such compounds, pharmaceutical compositions including one or more such compounds, methods of prepari...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: DWYER MICHAEL P, PARUCH KAMIL, GUZI TIMOTHY J, ALVAREZ CARMEN S
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:In its many embodiments, the present invention provides a novel class of amino-substituted pyrazolo[1,5-a]pyrimidine compounds as inhibitors of protein and/or checkpoint kinases, methods of preparing such compounds, pharmaceutical compositions including one or more such compounds, methods of preparing pharmaceutical formulations including one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the protein or checkpoint kinases using such compounds or pharmaceutical compositions. An illustrative compound is shown below: