3-(2-acylamino-1-hydroxyethyl)-morpholine derivatives and their use as bace inhibitors

3-(2-acylamino-1-hydroxyethyl)-morpholine derivatives and their use as bace inhibitors

The present invention provides BACE inhibitors of Formula (I); methods for their use and preparation, and intermediates useful for their preparation.

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Bibliographische Detailangaben
Hauptverfasser: BROUGHTON HOWARD BARFF, KOHN TODD JONATHAN, BUENO MELENDO ANA BELEN, HENRY, JR. KENNETH JAMES, GONZALEZ-GARCIA MARIA ROSARIO, HAHN PATRIC JAMES, SHEPHERD TIMOTHY ALAN, DALLY ROBERT DEAN, ERICKSON JON ANDRE, DURHAM TIMOTHY BARRETT, MCCARTHY JAMES RAY
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:The present invention provides BACE inhibitors of Formula (I); methods for their use and preparation, and intermediates useful for their preparation.