System for and method of positioning cells and determining cellular activity thereof

System for and method of positioning cells and determining cellular activity thereof

A device for positioning at least one cell in at least one addressable position, the device comprising a substrate (12) formed with at least one addressable pore (14) and at least one channel (16) embedded in the substrate and being held in fluid communication with the at least one pore. The at leas...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: BEN-JACOB ESHEL, SHAPIRA YOASH, GABAY TAMIR, BARUCHI ITAY, SEGEV RONEN, HULATA EYAL, HANEIN YAEL
Format: Patent
Sprache:eng
Schlagworte:
BEER
BIOCHEMISTRY
CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
DIAGNOSIS
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
IDENTIFICATION
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PERFORMING OPERATIONS
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
PHYSICS
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
SURGERY
TESTING
TRANSPORTING
VINEGAR
WINE
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Beschreibung
Zusammenfassung:A device for positioning at least one cell in at least one addressable position, the device comprising a substrate (12) formed with at least one addressable pore (14) and at least one channel (16) embedded in the substrate and being held in fluid communication with the at least one pore. The at least one pore and the at least one channel are designed and constructed such that an under-pressure formed in the at least one channel results in vacuum adherence of the at least one cell onto the at least one pore, such that a single cell is vacuum adhered onto a single pore. In one embodiment, the substrate is a non-conductive substrate and is further formed with one or more electrode structures (22), where each of the electrode structures is positioned in one of the pores. In an additional embodiment the device is designed to be locatable on an organ, such as the brain.