2-phenoxy- and 2-phenylsulfonamide derivatives with CCR3 antagonistic activity for the treatment of asthma and other inflammatory or immunological disorders

The present invention relates to a benzenesulfonamide derivative of formula (I), which is useful as an active ingredient of pharmaceutical preparations. The benzenesulfonamide derivatives of the present invention have CCR3 (CC type chemokine receptor) antagonistic activity, and can be used for the p...

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Hauptverfasser: MARUMO MAKIKO, NUNAMI NORIKO, BACON KEVIN, URBAHNS KLAUS, LI YINGFU, FUKUSHIMA KEIKO, SUGIMOTO HIROMI, MORIWAKI TOSHIYA, YOSHIDA NAGAHIRO, HASHIMOTO KENTARO, TSUNO NAOKI
Format: Patent
Sprache:eng
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Zusammenfassung:The present invention relates to a benzenesulfonamide derivative of formula (I), which is useful as an active ingredient of pharmaceutical preparations. The benzenesulfonamide derivatives of the present invention have CCR3 (CC type chemokine receptor) antagonistic activity, and can be used for the prophylaxis and treatment of diseases associated with CCR3 activity, in particular for the treatment of asthma, atopic dermatitis, allergic rhinitis and other inflammatory/immunological disorders. In said formula, X represents O or S; R4 represents formulae (a), (b), (c), (d), (e), (f), (g), (h), (i) or (j), the other substituents are as defined in claim 1.