Bioactive substance

The present invention provides a novel bioactive substance having an antitumor activity and a process for producing it, and a medical use thereof. Namely, it provides a 12-membered ring macrolide compound represented by the following formula obtained from the incubation solution of Streptomyces sp....

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	FUJITA MASANORI, OKUDA AKIFUMI, MIZUI YOSHIHARU, UENAKA TOSHIMITSU, YOSHIDA MASASHI, TAKEDA SUSUMU, YAMADA TOMONARI, IWATA MASAO, NAKASHIMA TAKASHI, NIIJIMA JUN, YAMAMOTO SATOSHI, YAMORI TAKAO, SAMESHIMA TOMOHIRO, OKAMOTO KIYOSHI, ASAI NAOKI, DOBASHI KAZUYUKI, NAGAI MITSUO, KOTAKE YOSHIHIKO, KOMEDA KEISUKE, KAWAMURA NAOTO, NORIHISA KOJI, TSUCHIDA TOSHIO, KISHI KUMIKO, SAKAI TAKASHI, MATSUFUJI MOTOKO
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention provides a novel bioactive substance having an antitumor activity and a process for producing it, and a medical use thereof. Namely, it provides a 12-membered ring macrolide compound represented by the following formula obtained from the incubation solution of Streptomyces sp. Mer. 11107 or a variant thereof, a pharmacologically acceptable salt thereof or a hydrate of them, and a process for producing it.