Method of screening cell death modulators

The invention provides methods and compositions for identifying agents which modulate cell death, indicated e.g. by the expression of caspase-2 and/or caspase-7, in GDNF family growth factor deprived neuronal or nonneuronal cells. The methods for identifying such agents find particular application i...

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Bibliographische Detailangaben
Hauptverfasser: ARUMAEE URMAS, YU LI-YING, SAARMA MART
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The invention provides methods and compositions for identifying agents which modulate cell death, indicated e.g. by the expression of caspase-2 and/or caspase-7, in GDNF family growth factor deprived neuronal or nonneuronal cells. The methods for identifying such agents find particular application in drug development.