Three dimensional format biochips

Three dimensional format biochips

A biochip is formed with a plurality of optically clear hydrogel cells attached to the top surface of a solid substrate in the form of an array. Each of the cells is formed of a hydrogel of polyethylene glycol, polypropylene glycol or a copolymer thereof having reactive isocyanate groups. Binding en...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: HAHN SOONKAP, PIRCHER TONY, MATSUMOTO SANDRA, DONG XIAOFAN, FAGNANI ROBERTO, TSINBERG PAVEL
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
COMBINATORIAL CHEMISTRY
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES
MEASURING
METALLURGY
PHYSICS
TESTING
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Beschreibung
Zusammenfassung:A biochip is formed with a plurality of optically clear hydrogel cells attached to the top surface of a solid substrate in the form of an array. Each of the cells is formed of a hydrogel of polyethylene glycol, polypropylene glycol or a copolymer thereof having reactive isocyanate groups. Binding entities are immobilized in these cells, which entities are effective to selectively hybridize to or sequester a target biomolecule. Different binding entities are immobilized in different cells in an array to create a biochip that can be used to assay for a number of target biomolecules.