Method and apparatus for sensing a time varying current passing through an ion channel

A capacitive sensing system is used to measure a time-varying ion current through a channel, such as an ion channel or protein pore. Such a capacitive system does not suffer problems of electrode corrosion and, when used with methods to control a build up of ion concentration, allows the use of meas...

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Bibliographische Detailangaben
Hauptverfasser: DUGAN REGINA E, HIBBS ANDREW D
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:A capacitive sensing system is used to measure a time-varying ion current through a channel, such as an ion channel or protein pore. Such a capacitive system does not suffer problems of electrode corrosion and, when used with methods to control a build up of ion concentration, allows the use of measurement volumes around the channel with dimensions on a scale of nanometers.