Substituted indolepyridinium as anti-infective compounds

Substituted indolepyridinium as anti-infective compounds

The present invention concerns the compounds of formula (I) their N-oxides, salts, stereoisomeric forms, racemic mixtures, prodrugs, esters and metabolites, wherein n is 1, 2 or 3; R1is H, CN, halo, aminoC(-O), C(-O)OH, C1-4alkyloxyC(-O), C1-4alkylC(-O), mono- or di(C1-4alkyl)aminoC(-O), arylaminoC(...

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Hauptverfasser: JOCHMANS DIRK EDWARD DESIRE, VAN DE VREKEN WIM, KESTELEYN BART RUDOLF ROMANIE, CANARD MAXIME FRANCIS JEAN-MARIE GHISLAIN, KINDERMANS NATALIE MARIA FRANCISCA, HERTOGS KURT, DE VROEY VERONIQUE CORINE PAUL, BETTENS EVA
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:The present invention concerns the compounds of formula (I) their N-oxides, salts, stereoisomeric forms, racemic mixtures, prodrugs, esters and metabolites, wherein n is 1, 2 or 3; R1is H, CN, halo, aminoC(-O), C(-O)OH, C1-4alkyloxyC(-O), C1-4alkylC(-O), mono- or di(C1-4alkyl)aminoC(-O), arylaminoC(-O), N-(aryl)-N-(C1-4alkyl)aminoC(-O), methanimidamidyl, N-hydroxy-methanimidamidyl, mono- or di(C1-4alkyl)methanimidamidyl, Het1 or Het2; R2 is H, C1-10alkyl, C2-10alkenyl, C3-7cycloalkyl, wherein said C1-10alkyl, C2-10alkenyl and C3-7cycloalkyl may be optionally substituted; R3 is nitro, cyano, amino, halo, hydroxy, C1-4alkyloxy, hydroxyC(-O), aminoC(-O), C1-4alkyloxyC(-O), mono- or di(C1-4alkyl)aminoC(-O), C1-4alkylC(-O), methanimidamidyl, mono- or di(C1-4alkyl)methanimidamidyl, N-hydroxy-methanimidamidyl or Het1; for use as a medicine. The invention further relates to a novel subgroup of the compounds of formula (I), and to compositions comprising compounds of formula (I).