Process for the synthesis C-2, C-3 substituted N-alkylated indoles useful as CPLA2 inhibitors

Process for the synthesis C-2, C-3 substituted N-alkylated indoles useful as CPLA2 inhibitors

The present invention provides method for making a compound of formula 1: comprising the steps of reacting compounds of formulas 2 and 3: to produce a compound of formula 4: wherein R1, R2, R3, R4 and R5 are defined as described herein. The compound of formula 4 is then converted to the compound of...

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Bibliographische Detailangaben
Hauptverfasser: RAVEENDRANATH PANOLIL, DEHNHARDT CHRISTOPH, BOYAJIAN ARA R, LEVENT MAHMUT, MICHALAK RONALD S, WINKLEY MICHAEL W, CANTIN MICHEL, GUINOSSO CHARLES, GHOSH MOUSUMI, VYVERBERG FREDERICK J, STOCKTON ALAN
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The present invention provides method for making a compound of formula 1: comprising the steps of reacting compounds of formulas 2 and 3: to produce a compound of formula 4: wherein R1, R2, R3, R4 and R5 are defined as described herein. The compound of formula 4 is then converted to the compound of formula 1. The invention further comprises compounds of formulas 3 and 4 and methods for making compounds of formulas 3 and 4.