Nanoparticle composite-coated glass microspheres for use in bioassays

A microsphere for use in a bioassay comprising a glass core coated with a nanoparticle composite comprising a bioactive probe is provided. The nanoparticle composite coating enhances the density of bioprobe loading on the surface of the microspheres, resulting in enhanced dynamic range and sensitivi...

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Hauptverfasser: KOURTAKIS KOSTANTINOS, CROKER KEVIN MICHAEL, PERRY MICHAEL P, PROBER JAMES M, DAMORE MICHAEL B, STULL PAUL DOUGLAS
Format: Patent
Sprache:eng
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Zusammenfassung:A microsphere for use in a bioassay comprising a glass core coated with a nanoparticle composite comprising a bioactive probe is provided. The nanoparticle composite coating enhances the density of bioprobe loading on the surface of the microspheres, resulting in enhanced dynamic range and sensitivity in bioassays. The particle may be used in detection systems where resonant light scattering properties of the particle are useful.