Substituted hydantoins

This invention relates to compounds of formula I: or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, and R6 are described in this application. These compounds inhibit the enzymes MEK 1 and MEK2, protein kinases that are components of the MAP kinase signal transduction pathway...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: HUBY NICHOLAS J. S, MORALES OMAR JOSE, MOLITERNI JOHN ANTHONY, KONG NORMAN, CHEN SHAOQING
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:This invention relates to compounds of formula I: or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, and R6 are described in this application. These compounds inhibit the enzymes MEK 1 and MEK2, protein kinases that are components of the MAP kinase signal transduction pathway and as such the compounds will have anti-hyperproliferative cellular activity.