Tramadol recovery process

A process for the resolution of isomeric tramadol mixtures comprising: providing a purification stock comprising both cis and trans tramadol; contacting the purification stock with an acid under conditions effective to form an acid salt of the cis and trans tramadol in the purification stock; and se...

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Bibliographische Detailangaben
Hauptverfasser:	SAXENA ASHVINI, PATHAK GUNJAN PRAMOD, DIKE SUNEEL YESHWANT, PAL VIRENDRA, GEHLOT JAYSINGH, SOUDAGAR SATISH RAJANIKANT, KUMAR ASHOK, KARDE RAHUL, BURUDKAR SANDEEP MADHAVRAO, GAUTAM PRASHANT, NELLITHANATH THANKACHEN BYJU, SARAVANAN MANAVALAN, SHAH CHIRAG HASMUKH
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS APPARATUS THEREFOR CHEMISTRY GENERAL METHODS OF ORGANIC CHEMISTRY METALLURGY ORGANIC CHEMISTRY
Online-Zugang:	Volltext bestellen
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Beschreibung
Zusammenfassung:	A process for the resolution of isomeric tramadol mixtures comprising: providing a purification stock comprising both cis and trans tramadol; contacting the purification stock with an acid under conditions effective to form an acid salt of the cis and trans tramadol in the purification stock; and separating the cis-tramadol acid salt from the trans-tramadol to obtain a purified cis-tramadol acid salt; and optionally converting the cis-tramadol acid salt to cis-tramadol or to a pharmaceutically active salt thereof.