Substituted pyrrolo[2.3-B]pyridines

Substituted pyrrolo[2.3-B]pyridines

Compounds represented by Formula (I): or stereoisomers or pharmaceutically acceptable salts thereof, are inhibitors of least two of the Abl, Aurora-A, Blk, c-Raf, cSRC, Src, PRK2, FGFR3, Flt3, Lck, Mek1, PDK-1, GSK3beta, EGFR, p70S6K, BMX, SGK, CaMKII, Tie-2, IGF-1R, Ron, Ret, and KDR kinases in ani...

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Hauptverfasser: AHMED SALEH, DAWSON GRAHAM, WENG QINGHUA ('FELIX'), PEGG NEIL ANTHONY, TAVARES PAULA, SAMBROOK SMITH COLIN PETER, SMYTH DON, SADIQ SHAZIA, STOLZ KATHRYN, BLOXHAM JASON, LI AN-HU, DONG HANQING, BARBA OSCAR, PANICKER BIJOY, STEINIG AMO G, FOREMAN KENNETH ('KEN'), WILKES ROBIN, COX MATTHEW, KITCHIN JOHN, SABA IMAAD, MA LIFU, GATTRELL WILLIAM
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:Compounds represented by Formula (I): or stereoisomers or pharmaceutically acceptable salts thereof, are inhibitors of least two of the Abl, Aurora-A, Blk, c-Raf, cSRC, Src, PRK2, FGFR3, Flt3, Lck, Mek1, PDK-1, GSK3beta, EGFR, p70S6K, BMX, SGK, CaMKII, Tie-2, IGF-1R, Ron, Ret, and KDR kinases in animals, including humans, for the treatment and/or prevention of various diseases and conditions such as cancer.