Metal complexes derivatized with folate for use in diagnostic and therapeutic applications

Diagnostic and therapeutic compositions in the form of complexes for enhancing transmembrane transport of a diagnostic or therapeutic agent and methods for their use. The complexes contain the alpha, gamma, or bis isomers of folate receptor-binding analogs of folate, a metal chelated by a ligand, an...

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Hauptverfasser:	WAGER RUTH E, NUNN ADRIAN D, LINDER KAREN E, RANGANATHAN RAMACHANDRAN S, RAMALINGAM KONDAREDDIAR, RAJU NATARANJAN, TWEEDLE MICHAEL F, WEDEKING PAUL W, ARUNACHALAM THANGAVEL
Format:	Patent
Sprache:	eng
Schlagworte:	DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROMTHE BODY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Diagnostic and therapeutic compositions in the form of complexes for enhancing transmembrane transport of a diagnostic or therapeutic agent and methods for their use. The complexes contain the alpha, gamma, or bis isomers of folate receptor-binding analogs of folate, a metal chelated by a ligand, and in one embodiment, a chemotherapeutic agent.