DNA encoding a human imidazoline receptor and ligand binding assay employing same

A cDNA encoding a human imidazoline receptor is described. The amino acid sequence of the entire imidazoline receptor protein is identified, as well as a C-terminal fragment believed to contain the imidazoline binding site of the receptor. The protein is highly unique in its sequence and may represe...

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Bibliographische Detailangaben
Hauptverfasser:	IVANOV TINA R, PILETZ JOHN E
Format:	Patent
Sprache:	eng
Schlagworte:	BUILDING BUILDINGS OR LIKE STRUCTURES FOR PARTICULAR PURPOSES CHAIRS FOR DENTISTRY CHEMISTRY FENCING FIXED CONSTRUCTIONS FUNERAL DEVICES HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MASTS MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY OPERATING TABLES OR CHAIRS ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SWIMMING OR SPLASH BATHS OR POOLS TENTS OR CANOPIES, IN GENERAL TESTING TRANSPORT OR ACCOMODATION FOR PATIENTS
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Beschreibung
Zusammenfassung:	A cDNA encoding a human imidazoline receptor is described. The amino acid sequence of the entire imidazoline receptor protein is identified, as well as a C-terminal fragment believed to contain the imidazoline binding site of the receptor. The protein is highly unique in its sequence and may represent the first in a novel family of receptor proteins. Methods of cloning the cDNA and expressing the imidazoline receptor in a host cell are described. Also, a screening method for identifying drugs that interact with the imidazoline receptor is described.