Oxa-and thiadiazoles and their use as metalloproteinase inhibitors

Oxa-and thiadiazoles and their use as metalloproteinase inhibitors

Compounds formula (IA) or (IB), wherein W represents HO(C-O)-, HONH(C-O)- or H(C-O)N(OH)-; X represents -O- or -S-; and R1, R2, and R3 are as defined in the description and claims, are inhibitors of matrix metalloproteinases, in particular MMP9 and/or MMP12.

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Bibliographische Detailangaben
Hauptverfasser: AYSCOUGH ANDREW PAUL, PAIN GILLES, GILLON JEAN-YVES, DAVIES STEPHEN JOHN
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:Compounds formula (IA) or (IB), wherein W represents HO(C-O)-, HONH(C-O)- or H(C-O)N(OH)-; X represents -O- or -S-; and R1, R2, and R3 are as defined in the description and claims, are inhibitors of matrix metalloproteinases, in particular MMP9 and/or MMP12.