Kappa agonist compounds and pharmaceutical formulations thereof

Compounds having kappa opioid agonist activity, compositions containing them and 5 method of using them as analgesics and pruritic agents are provided. The compounds of formulae I, II, III and IV have the structure: wherein X, X4, X5, X7, X9; R1, R2, R3, R4; and Y, Z and n are as described in the sp...

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Bibliographische Detailangaben
Hauptverfasser: ZHANG WEI YUAN, CHANG ANIH, KUMAR VIRENDRA, GAUL FORREST, FARRAR JOHN J, MARELLA MICHAEL ANTHONY, MAYCOCK ALAN L, DEHAVEN-HUDKINS DIANE L, KRUSE LAWRENCE I
Format: Patent
Sprache:eng
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Zusammenfassung:Compounds having kappa opioid agonist activity, compositions containing them and 5 method of using them as analgesics and pruritic agents are provided. The compounds of formulae I, II, III and IV have the structure: wherein X, X4, X5, X7, X9; R1, R2, R3, R4; and Y, Z and n are as described in the specification.