Process for preparing ondansetron hydrochloride dihydrate having a defined particle size
The invention provides a process for preparing ondansetron hydrochloride dihydrate particles in which at least about 70% of the particles have a particle size of less than 250 mum, comprising the steps of: (a) preparing a solution comprising ondansetron hydrochloride and water; and (b) adding the so...
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| Format: | Patent |
| Sprache: | eng |
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| Zusammenfassung: | The invention provides a process for preparing ondansetron hydrochloride dihydrate particles in which at least about 70% of the particles have a particle size of less than 250 mum, comprising the steps of: (a) preparing a solution comprising ondansetron hydrochloride and water; and (b) adding the solution into a precipitation medium which comprises a water-miscible nonsolvent for ondansetron hydrochloride, while maintaining the resulting mixture at a temperature of about 40° C. or less. |
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