Hybrid system for solubilizing pharmaceutically active substances in polymer matrices

Hybrid system for solubilizing pharmaceutically active substances in polymer matrices

The present invention is directed to a hybridized polymer matrix, a method of making such, and products incorporating such a matrix. The hybridized polymer matrix comprises a solvent-free polymer matrix base, a hybridized matrix comprising one or more poly(1-vinyl-2-pyrrolidones) and dimethyl sulfox...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: GAEDE CHRISTIAN, NIERLE JENS
Format: Patent
Sprache:eng
Schlagworte:
BANDAGES, DRESSINGS OR ABSORBENT PADS
DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF,TUBULAR STRUCTURES OF THE BODY, E.G. STENTS
FILTERS IMPLANTABLE INTO BLOOD VESSELS
FIRST-AID KITS
FOMENTATION
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROSTHESES
TREATMENT OR PROTECTION OF EYES OR EARS
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Beschreibung
Zusammenfassung:The present invention is directed to a hybridized polymer matrix, a method of making such, and products incorporating such a matrix. The hybridized polymer matrix comprises a solvent-free polymer matrix base, a hybridized matrix comprising one or more poly(1-vinyl-2-pyrrolidones) and dimethyl sulfoxide, and at least one active substance. The hybridized polymer matrix is useful in the preparation of transdermal therapeutic systems, particularly making possible the introduction of pharmaceutically active substances which are otherwise difficult to dissolve, such as ibuprofen, into a non-polar matrix.