Pyridine derivatives

This invention is to provide a process for producing 2-amino-4,6-disubstituted nicotinic acid ester analogs and salts thereof, comprising the reaction shown by the following scheme. The ester analogs can be prepared in one pot, and in good yield by using tertiary alkyl cyanoacetate. Furthermore, the...

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Bibliographische Detailangaben
Hauptverfasser:	SAKAKIBARA SACHIKO, KADONO HIROSHI, MASUDA TSUTOMU, UMEDA MASAOMI, ZIEGELBAUER KARL B, YOSHIRO TAKASHI, KOMURA HIROSHI, SHINTANI TAKUYA, SATO HIROKI, KORIYAMA YUJI, SHIMADA MITSUIYUKI, LOWINGER TIMOTHY B, FUCHIKAMI KINJI, MURATA TOSHIKI
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	This invention is to provide a process for producing 2-amino-4,6-disubstituted nicotinic acid ester analogs and salts thereof, comprising the reaction shown by the following scheme. The ester analogs can be prepared in one pot, and in good yield by using tertiary alkyl cyanoacetate. Furthermore, the method is useful for preparing derivatives of various analogs of the ester, e.g. alkyl substituted and aryl substituted analogs.