Methods for the synthesis of pyridoxamine

The invention provides non-oxidative methods for the large scale manufacture of pyridoxamine (I) (4-aminomethyl-3-hydroxy-5-hydroxymethyl-2-methylpyridine): and salts thereof. The invention also provides intermediate compounds for the synthesis of pyridoxamine, as well as compositions and methods fo...

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Hauptverfasser: KHALIFAH RAJA, KOELLNER CHRISTOPH, KEILITZ ROLAND, DEGENHARDT THORSTEN, BRAND STEPHEN ROBERT
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creator KHALIFAH RAJA
KOELLNER CHRISTOPH
KEILITZ ROLAND
DEGENHARDT THORSTEN
BRAND STEPHEN ROBERT
description The invention provides non-oxidative methods for the large scale manufacture of pyridoxamine (I) (4-aminomethyl-3-hydroxy-5-hydroxymethyl-2-methylpyridine): and salts thereof. The invention also provides intermediate compounds for the synthesis of pyridoxamine, as well as compositions and methods for the treatment and/or prevention of conditions associated with the formation of post-Amadori advanced glycation end-products.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title Methods for the synthesis of pyridoxamine
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