Reduced side-effect hemoglobin compositions

Reduced side-effect hemoglobin compositions

The invention relates to novel hemoglobin compositions, particularly novel recombinant mutant hemoglobin compositions, which eliminate or substantially reduce 1) the creation of heart lesions, 2) gastrointestinal discomfort, 3) pressor effects, and 4) endotoxin hypersensitivity associated with the a...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: SCHICK MICHAEL R, FOSTER DAVID L, TRIMBLE STEPHEN P, LEMON DOUGLAS D, APOSTOL IZYDOR Z, HARTMAN JAMES C, MOORE EDWIN G, PEREIRA DAVID, RICHARDS JANE P, BURHOP KENNETH E, LEE GEOFFREY F, DOYLE MICHAEL P, BRUCKER ERIC A, LOOKER DOUGLAS L, HAI TON-THAT, GLASCOCK CHRISTOPHER B
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The invention relates to novel hemoglobin compositions, particularly novel recombinant mutant hemoglobin compositions, which eliminate or substantially reduce 1) the creation of heart lesions, 2) gastrointestinal discomfort, 3) pressor effects, and 4) endotoxin hypersensitivity associated with the administration of extracellular hemoglobin compositions in various therapeutic applications. Applications described include treatments for anemia, head injury, hemorrhage or hypovolemia, ischemia, cachexia, sickle cell crisis and stroke; enhancing cancer treatments; stimulating hematopoiesis; improving repair of physically damaged tissues; alleviating cardiogenic shock; and shock resuscitation.