Structures and methods for testing programmable logic devices having mixed-fabric architectures

Structures and methods for testing a re-programmable logic block embedded in a one-time programmable fabric in a PLD. The re-programmable logic block is tested without using the one-time programmable resources needed for implementing user circuits, by including a multiple input signature register (MISR) circuit coupled to receive output data from the re-programmable logic portion of the PLD. In some embodiments, a tester operating at a first and lower clock frequency can be used to test a re-programmable logic block operating at a second and higher clock frequency. In some of these embodiments, the one-time programmable fabric is tested at the first clock frequency.