N-formyl hydroxylamine derivatives as inhibitors of bacterial polypeptide formylase for treating microbial infections

Compounds of formula (I) are antibacterial or antiprotozoal agents for treatment of infections in humans and non-human mammals, wherein: Z represents a radical of formula -N(OH)CH(-O) or formula C(-O)NH(OH); R1 represents hydrogen, methyl or trifluromethyl, or except when Z is a radical of formula -...

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Hauptverfasser:	BECKETT PAUL RAYMOND, LAUNCHBURY STEVEN, PAIN GILLES, PRATT LISA MARIE
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator	BECKETT PAUL RAYMOND LAUNCHBURY STEVEN PAIN GILLES PRATT LISA MARIE
description	Compounds of formula (I) are antibacterial or antiprotozoal agents for treatment of infections in humans and non-human mammals, wherein: Z represents a radical of formula -N(OH)CH(-O) or formula C(-O)NH(OH); R1 represents hydrogen, methyl or trifluromethyl, or except when Z is a radical of formula -N(OH)(-O), a hydroxy, halo or amino group; R2 represents a group R10-(X)n-(ALK)m- wherein R10, ALK, X, m and n are as defined in the specification; R3 represents hydrogen, (C1-C6) alkyl or phenyl(C1-C6)alkyl-; and R5 and R6 are as defined in the specification.
format	Patent
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subjects	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title	N-formyl hydroxylamine derivatives as inhibitors of bacterial polypeptide formylase for treating microbial infections
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