N-formyl hydroxylamine derivatives as inhibitors of bacterial polypeptide formylase for treating microbial infections

N-formyl hydroxylamine derivatives as inhibitors of bacterial polypeptide formylase for treating microbial infections

Compounds of formula (I) are antibacterial or antiprotozoal agents for treatment of infections in humans and non-human mammals, wherein: Z represents a radical of formula -N(OH)CH(-O) or formula C(-O)NH(OH); R1 represents hydrogen, methyl or trifluromethyl, or except when Z is a radical of formula -...

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Hauptverfasser: BECKETT PAUL RAYMOND, LAUNCHBURY STEVEN, PAIN GILLES, PRATT LISA MARIE
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:Compounds of formula (I) are antibacterial or antiprotozoal agents for treatment of infections in humans and non-human mammals, wherein: Z represents a radical of formula -N(OH)CH(-O) or formula C(-O)NH(OH); R1 represents hydrogen, methyl or trifluromethyl, or except when Z is a radical of formula -N(OH)(-O), a hydroxy, halo or amino group; R2 represents a group R10-(X)n-(ALK)m- wherein R10, ALK, X, m and n are as defined in the specification; R3 represents hydrogen, (C1-C6) alkyl or phenyl(C1-C6)alkyl-; and R5 and R6 are as defined in the specification.