Process for the preparation of echinocandin derivatives

Process for the preparation of echinocandin derivatives

A subject of the invention is a process for the preparation of the compounds of formula (I): R being as defined in the description as well as their salts, the intermediates, the use of the dihydrochloride as a medicament and the pharmaceutical compositions containing them. The process for preparing...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: BOFFELLI PHILIPPE, BROUILLARD AGNES, DROUX SERGE, FERROUD DIDIER, PALADINO JOSEPH, COLLADANT COLETTE, LEMAITRE GUY, ELTER MICHEL
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:A subject of the invention is a process for the preparation of the compounds of formula (I): R being as defined in the description as well as their salts, the intermediates, the use of the dihydrochloride as a medicament and the pharmaceutical compositions containing them. The process for preparing formula (I) leads to greater than 50% yields of isomer A, and its intended use, e.g. as an antifungal medicament.