Heteroarylakanoic acids as intergrin receptor antagonists

The present invention relates to a class of compounds represented by formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of Formula (I), and methods of selectively antagonizing the alphanubeta3 and/or the alphanubeta5 integrin without significa...

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Bibliographische Detailangaben
Hauptverfasser:	CHEN BARBARA B, PENNING THOMAS D, MOHLER SCOTT B, NAGARAJAN SRINIVASAN RAJ, SCHRETZMAN LORI A, CHANDRAKUMAR NIZAL S, LU HWANG-FUN, RUSSELL MARK, DEVADAS BALEKUDRU, SPANGLER DALE P, KHANNA ISH KUMAR, TOLLEFSON MICHAEL B, BOYS MARK L
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to a class of compounds represented by formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of Formula (I), and methods of selectively antagonizing the alphanubeta3 and/or the alphanubeta5 integrin without significantly antagonizing the IIb/IIIa integrin.