Process for preparing cefdinir

The present invention relates to a novel process for the preparation of a cefdinir by reacting O-acetyl thioester of Formula I with in the presence of a base in suitable solvent wherein R' represents H or any carboxyl protecting group, and then converting to the cefdinir by the removal of prote...

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Bibliographische Detailangaben
Hauptverfasser:	SIVAKUMARAN MEENAKHSHISUNDERAM, DANDALA RAMESH, KORRAPATI V. V. PRASADA RAO
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION ORPROCESSING OF GOODS GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE
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Beschreibung
Zusammenfassung:	The present invention relates to a novel process for the preparation of a cefdinir by reacting O-acetyl thioester of Formula I with in the presence of a base in suitable solvent wherein R' represents H or any carboxyl protecting group, and then converting to the cefdinir by the removal of protecting groups. This invention also relates to making the cefdinir using a novel process to prepare the O-acetyl thioester intermediate (Formula I) by condensing (Z)-2-(2-amino-4-thiazolyl)-2-acetyloxyiminoacetic acid with bis(benzothiazol-2-yl)disulphide in the presence of triphenylphosphine and a base in a suitable solvent.