Ligand-controlled regulation of endogenous gene expression

Disclosed herein are compositions comprising an engineered zinc finger protein and a nuclear hormone receptor transcriptional control domain, polynucleotides encoding one or more components of the compositions, methods of making the compositions and methods of using these compositions, for example t...

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Bibliographische Detailangaben
Hauptverfasser: COX, III GEORGE NORBERT, CASE CASEY CHRISTOPHER, JARVIS ERIC EDWARD, SPRATT SHARON KAYE, EISENBERG STEPHEN P
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:Disclosed herein are compositions comprising an engineered zinc finger protein and a nuclear hormone receptor transcriptional control domain, polynucleotides encoding one or more components of the compositions, methods of making the compositions and methods of using these compositions, for example to modulate gene expression and/or to generate transgenic plants or animals.