Crystalline anhydrous and monohydrate benzoate salts of (2'S,3S)-3-hydroxy-N-(2-[N-methyl-N-4-(N-propylamino-carbonyl)phenyl]amino-2-phenyl)-ethylpyrrolidine

Crystalline anhydrous and monohydrate benzoate salts of (2'S,3S)-3-hydroxy-N-(2-[N-methyl-N-4-(N-propylamino-carbonyl)phenyl]amino-2-phenyl)-ethylpyrrolidine

A process for preparing an anhydrous benzoate salt in crystalline form having the formula I: and the corresponding benzoate monohydrate in crystalline form. The benzoate salts and pharmaceutical compositions thereof are selective kappa-receptor agonists, and are useful as analgesics, anesthetics, an...

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Bibliographische Detailangaben
Hauptverfasser: QUALLICH GEORGE J, CASTALDI MICHAEL J
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:A process for preparing an anhydrous benzoate salt in crystalline form having the formula I: and the corresponding benzoate monohydrate in crystalline form. The benzoate salts and pharmaceutical compositions thereof are selective kappa-receptor agonists, and are useful as analgesics, anesthetics, anti-inflammatory or neuroprotective agents, or in the treatment of arthritis, stroke or functional bowel disease.