Process for preparing the antiviral agent [1S-(1alpha,3 alpha,4beta )]-2-amino-1,9-dihydro-9-[4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one

Process for preparing the antiviral agent [1S-(1alpha,3 alpha,4beta )]-2-amino-1,9-dihydro-9-[4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one

Processes are disclosed for preparing the antiviral agent entecavir. A resin adsorption process for the isolation and purification of entecavir is also disclosed. Various intermediates useful in the preparation of entecavir are also disclosed.

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Bibliographische Detailangaben
Hauptverfasser: KUCERA DAVID J, VEMISHETTI PURUSHOTHAM, PRASAD SIVA JOSYULA, PATEL SUNIL S, SHI ZHONGPING, LIANG JING, RIJHWANI SUSHIL K, SINGH AMBARISH K, BIEN JEFFREY T, LEWIS CHARLES, BANERJEE AMIT, ZHOU MAOTANG X, THOTTATHIL JOHN, CHEN CHUNG-PIN H, PATEL RAMESH N, STOJANOVIC MILAN, PENDRI YADAGIRI R, CHAN YEUNG YU, WANG SHAOPENG, EVANS JEFFREY M, POLNIASZEK RICHARD P, KRONENTHAL DAVID R, POWERS GERALD L, KRISHNAMURTY DHILEEPKUMAR
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:Processes are disclosed for preparing the antiviral agent entecavir. A resin adsorption process for the isolation and purification of entecavir is also disclosed. Various intermediates useful in the preparation of entecavir are also disclosed.