Imidazo-pyrimidine derivatives as ligands for GABA receptors

Imidazo-pyrimidine derivatives as ligands for GABA receptors

A class of imidazo[1,2-alpha]pyrimidine derivatives, substituted at the 3-position by an optionally substituted five-membered or six-membered heteroaromatic ring, are selective ligands for GABAA receptors, in particular having good affinity for the alpha2 and/or alpha3 and/or alpha5 subunit thereof,...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: MOORE KEVIN WILLIAM, STREET LESLIE JOSEPH, BLACKABY WESLEY PETER, CHAMBERS MARK STUART, GOODACRE SIMON CHARLES, JONES PHILIP, MAXEY ROBERT JAMES, MACLEOD ANGUS MURRAY, HALLETT DAVID JAMES, LEWIS RICHARD THOMAS, CASTRO PINEIRO JOSE LUIS
Format: Patent
Sprache:eng
Schlagworte:
APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:A class of imidazo[1,2-alpha]pyrimidine derivatives, substituted at the 3-position by an optionally substituted five-membered or six-membered heteroaromatic ring, are selective ligands for GABAA receptors, in particular having good affinity for the alpha2 and/or alpha3 and/or alpha5 subunit thereof, and are accordingly of benefit in the treatment and/or prevention of adverse conditions of the central nervous system, including anxiety, convulsions and cognitive disorders.