Piperazine derivatives and their use as anti-inflammatory agents

This invention is directed to acyl piperazine derivatives of formula (Ia): wherein R1a, R2, R3, R4, R5 and R6 are defined herein, which are useful as anti-inflammatory agents. This invention is also directed to other acyl piperazine derivatives, pharmaceutical compositions containing the compounds o...

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Bibliographische Detailangaben
Hauptverfasser:	HESSELGESSER JOSEPH E, GHANNAM AMEEN F, LIANG MEINA, ZHAO ZUCHUN, HORUK RICHARD, MAY KAREN B, WEI GUO PING, MORRISSEY MICHAEL M, NG HOWARD P, BUCKMAN BRAD O, SHAW KENNETH J, MONAHAN SEAN D, BAUMAN JOHN G, ISLAM IMADUL, XU WEI, ZHENG WEI
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	This invention is directed to acyl piperazine derivatives of formula (Ia): wherein R1a, R2, R3, R4, R5 and R6 are defined herein, which are useful as anti-inflammatory agents. This invention is also directed to other acyl piperazine derivatives, pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat inflammatory disorders in humans.