6-membered heterocyclic compounds useful for selective inhibition of the coagulation cascade

The present invention relates to compounds, and prodrugs thereof, compositions and methods useful for preventing and treating thrombotic conditions in mammals. The compounds of the present invention, and prodrugs thereof, selectively inhibit certain proteases of the coagulation cascade.

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Bibliographische Detailangaben
Hauptverfasser:	NEUMANN WILLIAM L, RUEPPEL MELVIN L, CASE BRENDA, WEBBER RONALD K, LONG SCOTT, MOORMANN ALAN E, GARLAND DANNY J, PARLOW JOHN J, HAYES MICHAEL J, SNYDER JEFFERY S, SOUTH MICHAEL S, HUANG HORNGIH, TRUJILLO JOHN, JONES DARIN E, HUANG WEI, TOTH MIHALY V, SCHOLTEN JEFFREY A
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to compounds, and prodrugs thereof, compositions and methods useful for preventing and treating thrombotic conditions in mammals. The compounds of the present invention, and prodrugs thereof, selectively inhibit certain proteases of the coagulation cascade.