Compounds and their use as positive AMPA receptor modulators

Compounds and their use as positive AMPA receptor modulators

The invention provides novel compounds represented by general formula (I) wherein the bond represented by the broken line may be a single, double bond or absent; and if the bond is absent, then the nitrogen is substituted with a hydrogen and R2; X represents SO2 or C-O of CH2; Y represents -CH(R4)-,...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: SCHEEL-KRUEGER JOERGEN, LARSEN MOGENS, GOULIAEV ALEX HAAHR, OLSEN GUNNAR M, JOHANSEN TINA HOLM, NIELSEN ELSEBET OESTERGAARD, VARMING THOMAS, MATHIESEN CLAUS
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The invention provides novel compounds represented by general formula (I) wherein the bond represented by the broken line may be a single, double bond or absent; and if the bond is absent, then the nitrogen is substituted with a hydrogen and R2; X represents SO2 or C-O of CH2; Y represents -CH(R4)-, -N(R4)-CH2-, O; and the meaning of R2, R3, R4, R5, R6, R7, and R8 are as defined in the application. The compounds are useful as positive modulators of the AMPA-receptor.