Cardiac-cell specific enhancer elements and uses thereof

The invention features cardiac cell-specific enhancer elements derived from Csx/Nkx2.5 regulatory regions. These enhancer elements are useful, for example, for (i) regulating gene expression in cardiac cells, (ii) inducing stem cells (e.g., embryonic stem cells or bone marrow stem cells) to differen...

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Hauptverfasser:	LEE IKE W, IZUMO SEIGO
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention features cardiac cell-specific enhancer elements derived from Csx/Nkx2.5 regulatory regions. These enhancer elements are useful, for example, for (i) regulating gene expression in cardiac cells, (ii) inducing stem cells (e.g., embryonic stem cells or bone marrow stem cells) to differentiate as cardiomyocytes, and (iii) identifying factors that induce the differentiation of stem cells as cardiomyocytes.