Process for the isolation and purification of mevinolin

Process for the isolation and purification of mevinolin

In a process for preparing mevinolin by fermentation of a biomass in a fermentation liquor, which includes dissolving mevinolin from the biomass into the fermentation liquor, and separating the biomass from the fermentation liquor to obtain a separated fermentation liquor, separating the mevinolin f...

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Hauptverfasser: DEAK LAJOS, JAKAB ATTILA, MATYAS SZABOLCS, BAGDI ILONA, ILKOEY EVA, AMBRUS GABOR, KOVACS VERA, SZABO ISTVAN, HORVATH GYULA, LANG ILDIKO, MORAVCSIK IMRE, ANDOR ATTILA, SZABO CSABA, HOEGYE IRMA, BALINT JANOS, SCHEIDL ZSUZSANNA, KERI VILMOS, SZEKELY IMRE, JEKKEL ANTONIA, DELI ETELKA, SZTARAY ZSUZSANNA, ESZENYI LASZLO
Format: Patent
Sprache:eng
Schlagworte:
BEER
BIOCHEMISTRY
CHEMISTRY
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
SPIRITS
VINEGAR
WINE
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Beschreibung
Zusammenfassung:In a process for preparing mevinolin by fermentation of a biomass in a fermentation liquor, which includes dissolving mevinolin from the biomass into the fermentation liquor, and separating the biomass from the fermentation liquor to obtain a separated fermentation liquor, separating the mevinolin from the separated fermentation liquor, and recovering the end product, the improvement which comprises carrying out the dissolving at a pH between 7.5 and about 10, and the separating of the mevinolin is carried out at a pH between about 4.5 and about 1.