Phenyl-and phenylalkyl-substituted ethanolamines and ethylenediamines

Compounds of formula 1,wherein:R is hydrogen, hydroxy, CF3, NO2, CN, halogen, C1-C8-alkyl, or C1-C8-alkoxy;R , R , and R independently of one another are hydrogen, C1-C8-alkyl, hydroxy, NO2, CN, C1-C8-alkoxyl, CF3, or halogen;R and R independently of one another are hydrogen or a group consisting of C1-C8-alkyl, C2-C8-alkenyl, C3-C8-alkynyl, C3-C8-cycloalkyl, C3-C8-cycloalkyl-C1-C6-alkylene, C5-C8-cycloalkenyl, C5-C8-cycloalkenyl-C1-C6-alkylene, C6-C10-aryl, and C6-C10-aryl-C1-C6-alkylene, each optionally substituted by a group consisting of C1-C6-alkyl, C2-C6-alkenyl, halogen, C1-C6-alkyloxy, -NH2, -NH(C1-C4-alkyl), -N(C1-C4-alkyl)2, hydroxy, =O, -COOH, -CO-OC1-C4-alkyl, -CONH2, -CONH(C1-C4-alkyl), -CON(C1-C4-alkyl)2, and CF3, orR and R together with the nitrogen atom are a saturated or unsaturated 5-, 6-, 7-, or 8-membered heterocyclic group optionally containing one or two further heteroatoms consisting of sulfur, oxygen, and nitrogen, and optionally mono-, di-, or trisubstituted by a group consisting of C1-C4-alkyl, hydroxy, =O, -COOH, -CO-OC1-C4-alkyl, -CONH2, -CONH(C1-C4-alkyl), -CON(C1-C4-alkyl)2, halogen, and benzyl;X is oxygen, -NH-, -N(CHO)-, -N(CO-C1-C6-alkyl), -N(C1-C6-alkyl), or -N(C3-C6-cycloalkyl-C1-C4-alkylene); andA is a group consisting of C1-C6-alkylene, C2-C6-alkenylene, and C3-C6-alkynylene, each optionally substituted by a group consisting of halogen, =O, and hydroxy, or an optical isomer, enantiomer, tautomer, free base, or pharmacologically acceptable acid addition salt thereof; methods of making such compounds; pharmaceutical compositions thereof, and their use in treating or preventing certain diseases.