Process for stereoselective synthesis of prostacyclin derivatives

Process for stereoselective synthesis of prostacyclin derivatives

An improved method is described for making 9-deoxy-PGF1-type compounds. In contrast to the prior art, the method is stereoselective and requires fewer steps than the known methods for making these compounds. The invention also relates to novel intermediates prepared during the synthesis of the 9-deo...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: STASZEWSKI JAMES P, PENMASTA RAJU, GUO LIANG, RAO MUNAGALA S, MORIARTY ROBERT M
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:An improved method is described for making 9-deoxy-PGF1-type compounds. In contrast to the prior art, the method is stereoselective and requires fewer steps than the known methods for making these compounds. The invention also relates to novel intermediates prepared during the synthesis of the 9-deoxy-PGF1-type compounds.