Enantioselective bioreduction for the preparation of integrin receptor antagonist intermediates

The present invention relates to a novel enantioselective bioreduction using a yeast microorganism for the preparation of the chiral allylic alcohols of structural formula I (R is hydrogen or methyl) which are useful in the asymmetric synthesis of integrin alphavbeta3 receptor antagonists.

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Bibliographische Detailangaben
Hauptverfasser:	TELARI KATHLEEN A, STURR MICHAEL G, NTI-GYABAAH JOSEPH, GBEWONYO KODZO, BOYD RUSSELL FIELDON, MCWILLIAMS JAMES CHRISTOPHER, POLLARD DAVID J
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to a novel enantioselective bioreduction using a yeast microorganism for the preparation of the chiral allylic alcohols of structural formula I (R is hydrogen or methyl) which are useful in the asymmetric synthesis of integrin alphavbeta3 receptor antagonists.