Process for the preparation of amorphous atorvastatin calcium

The invention relates to a process for the preparation of amorphous atorvastatin calcium by recrystallization of crude atorvastatin from an organic solvent which comprises dissolving crude amorphous atorvastatin calcium in a lower alkanol containing 2-4 carbon atoms or a mixture of such alkanols und...

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Hauptverfasser: GREFF ZOLTAN, NAGY PETER KOTAY, DONATH GYORGYI VERECZKEYNE, BARTA FERENC, NAGY KALMAN, RATKAI ZOLTAN, SERES PETER, BARKOCZY JOZSEF, BALAZS LASZLO, KIRALLYI ZSUZSA SZENT, SIMIG GYULA, DOMAN IMRE
Format: Patent
Sprache:eng
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Zusammenfassung:The invention relates to a process for the preparation of amorphous atorvastatin calcium by recrystallization of crude atorvastatin from an organic solvent which comprises dissolving crude amorphous atorvastatin calcium in a lower alkanol containing 2-4 carbon atoms or a mixture of such alkanols under heating and isolating the amorphous atorvastatin calcium precipitated after cooling. The atorvastatin calcium obtained is a known valuable agent useful in treating hyperlipidemia and hypercholestrolemia.