Process for production of optically active pyrroloazepine derivatives

It is provided a method for preparing the pyrroloazepine derivatives, especially in optically active form useful as drugs, by low-priced and simple method and in industrial applicable scale, represented by the following formula (I):wherein Z represents optionally substituted phenyl group, which comp...

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Hauptverfasser: MIZUNO AKIRA, MURAISHI TERUO, SEKIUCHI KAZUTO, NAGATA TAKUSHI
Format: Patent
Sprache:eng
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Zusammenfassung:It is provided a method for preparing the pyrroloazepine derivatives, especially in optically active form useful as drugs, by low-priced and simple method and in industrial applicable scale, represented by the following formula (I):wherein Z represents optionally substituted phenyl group, which comprises; a process for the asymmetric reduction of ketone compound with metal hydride compound and alcohol compound in the presence of optically active cobalt complex catalyst, and a process for the purification of the resulting compound.