(4-oxo-2-pyrimidinyl)thioalkyl compounds useful as AICARFT inhibitors

(4-oxo-2-pyrimidinyl)thioalkyl compounds useful as AICARFT inhibitors

Compounds of the formula:(where R1, R2 and R3 are defined in the specification) are inhibitors of AICARFT. These compounds, as well as their pharmaceutically acceptable salts, solvents, prodrugs, and pharmaceutically active metabolites, are useful in pharmaceutical compositions for treating diseases...

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Bibliographische Detailangaben
Hauptverfasser: ROMINES, III WILLIAM H, PALMER CYNTHIA L, BLECKMAN TED M, VARNEY MICHAEL D
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:Compounds of the formula:(where R1, R2 and R3 are defined in the specification) are inhibitors of AICARFT. These compounds, as well as their pharmaceutically acceptable salts, solvents, prodrugs, and pharmaceutically active metabolites, are useful in pharmaceutical compositions for treating diseases such as cancer.