Process for the preparation of pseudomonic acid a antibiotic by microbiological method

A procedure for the preparation of pseudomonic acid A comprising submerged cultivation of a Pseudomonas bacterium strain capable of biosynthesis of the substantially pure pseudomonic acid A in aerated conditions via fermentation; and isolation of the desired compound is disclosed. In particular, the...

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Hauptverfasser: BARTA ISTVAN, MOZES NEE SUTO JULIANNA, BALOGH GABOR, SZELL VALERIA, ALBRECHT KAROLY, SZABO ISTVAN M, ERDEI JANOS, PETROCZKI MAGDOLNA, GULYAS EVA, LANG ILDIKO, TEDGES ANIKO
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Sprache:eng
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Zusammenfassung:A procedure for the preparation of pseudomonic acid A comprising submerged cultivation of a Pseudomonas bacterium strain capable of biosynthesis of the substantially pure pseudomonic acid A in aerated conditions via fermentation; and isolation of the desired compound is disclosed. In particular, the procedure of the present invention comprises cultivation of the Pseudomonas sp. bacterium strain No. 19/26 deposited under accession No. NCAIM(P)B 001235 in the National Collection of the Agricultural and Industrial Microorganisms, Budapest, Hungary, or its pseudomonic acid A-producing mutant or variant, on a medium at a temperature of between about 20° C. and 30° C. containing organic nitrogen and carbon sources and, optionally, mineral salts.