Process for mass production of GMP paclitaxel and related taxanes

A process for the purification of paclitaxel and/or cephalomannine and/or 10-DAB III and/or 9-DHAB III is described. A series of extractions, separations, and purifications provides these products in commercial quantities with high purity. The source for these natural products is from readily availa...

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Hauptverfasser: KASITU GERTRUDE C, NOAH JAPHETH, KHAN QASIM
Format: Patent
Sprache:eng
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Zusammenfassung:A process for the purification of paclitaxel and/or cephalomannine and/or 10-DAB III and/or 9-DHAB III is described. A series of extractions, separations, and purifications provides these products in commercial quantities with high purity. The source for these natural products is from readily available renewable biomaterials, such as leaves and stems from the yew, T. canadensis.